منابع مشابه
Regulating phage therapy
I n a note published in The Lancet in December 1915, Frederic Twort described the discovery of an infectious, filterable agent that causes the glassy transformation and eventual killing of bacteria, now identified as Staphylococcus hyicus [1]. Two years later, Félix d’Herelle independently described an invisible microbe antagonistic to dysentery bacilli in a note to the Comptes Rendus de l’Acad...
متن کاملPhage therapy
Bacteriophage therapy, the use of viruses that infect bacteria as antimicrobials, has been championed as a promising alternative to conventional antibiotics. Although in the laboratory bacterial resistance against phages arises rapidly, resistance so far has been an only minor problem for the effectiveness of phage therapy. Resistance to antibiotics, however, has become a major issue after deca...
متن کاملUnexploited opportunities for phage therapy
(2015) Unexploited opportunities for phage therapy. A Surprising Twist on Bacteriophage Therapy Bacterial infections have always been a threat to human health. The first available systemic antibiotics, in early twentieth century, were initially seen as truly miraculous drugs, providing a powerful tool to combat bacterial infections and increasing human life span. Deluded by their exceptional an...
متن کاملPhage therapy: facts and fiction.
Recent examples of the use of bacteriophages in controlling bacterial infections are presented, some of which show therapeutic promise. The therapeutic use of bacteriophages, possibly in combination with antibiotics, may be a valuable approach. However, it is also quite clear that the safe and controlled use of phage therapy will require detailed information on the properties and behavior of sp...
متن کاملPhage fitness may help predict phage therapy efficacy
We isolated 6 phages from 2 environmental water sources and assessed their ability to treat Pseudomonas aeruginosa infection of Drosophila melanogaster. We found all 6 phages were able to significantly increase mean survival time (MST) of infected D. melanogaster. Although phage traits, such as adsorption rate, burst size, and lysis time, varied significantly among these phages, none of the tra...
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ژورنال
عنوان ژورنال: EMBO reports
سال: 2017
ISSN: 1469-221X,1469-3178
DOI: 10.15252/embr.201643250